Application of Polymeric Nanocarriers for Enhancing the Bioavailability of Antibiotics at the Target Site and Overcoming Antimicrobial Resistance

Antimicrobial resistance is one of the greatest threats to global health. Although efforts in antibiotic drug discovery continue play a pivotal role, this solution alone probably will not be enough ensure required level infection control future. New strategies and innovative modes action are desperately needed preserve effectiveness antimicrobials. Accordingly, delivery based on polymeric nanoparticles possible methods that has been recently explored improve their pharmacokinetic profile. Through optimized access antibiotics sites action, nanocarriers can unlock full potential cargoes, extend antimicrobial spectrum, reduce dose while preserving efficacy. Additionally, use an antibiotic-loaded nanocarrier also considered steady as novel molecules continuously developed incorporated into platform. This review describes present state enhancing treatment, including improved properties restored efficacy against drug-resistant bacteria. current challenges future direction field discussed.